COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Identifieur interne : 000855 ( Main/Exploration ); précédent : 000854; suivant : 000856COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Auteurs : Lennard Y W. Lee [Royaume-Uni] ; Jean-Baptiste Cazier [Royaume-Uni] ; Thomas Starkey [Royaume-Uni] ; Sarah E W. Briggs [Royaume-Uni] ; Roland Arnold [Royaume-Uni] ; Vartika Bisht [Royaume-Uni] ; Stephen Booth [Royaume-Uni] ; Naomi A. Campton [Royaume-Uni] ; Vinton W T. Cheng [Royaume-Uni] ; Graham Collins [Royaume-Uni] ; Helen M. Curley [Royaume-Uni] ; Philip Earwaker [Royaume-Uni] ; Matthew W. Fittall [Royaume-Uni] ; Spyridon Gennatas [Royaume-Uni] ; Anshita Goel [Royaume-Uni] ; Simon Hartley [Royaume-Uni] ; Daniel J. Hughes [Royaume-Uni] ; David Kerr [Royaume-Uni] ; Alvin J X. Lee [Royaume-Uni] ; Rebecca J. Lee [Royaume-Uni] ; Siow Ming Lee [Royaume-Uni] ; Hayley Mckenzie [Royaume-Uni] ; Chris P. Middleton [Royaume-Uni] ; Nirupa Murugaesu [Royaume-Uni] ; Tom Newsom-Davis [Royaume-Uni] ; Anna C. Olsson-Brown [Royaume-Uni] ; Claire Palles [Royaume-Uni] ; Thomas Powles [Royaume-Uni] ; Emily A. Protheroe [Royaume-Uni] ; Karin Purshouse [Royaume-Uni] ; Archana Sharma-Oates [Royaume-Uni] ; Shivan Sivakumar [Royaume-Uni] ; Ashley J. Smith [Royaume-Uni] ; Oliver Topping [Royaume-Uni] ; Chris D. Turnbull [Royaume-Uni] ; Csilla Várnai [Royaume-Uni] ; Adam D M. Briggs [Royaume-Uni] ; Gary Middleton [Royaume-Uni] ; Rachel Kerr [Royaume-Uni]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Appréciation des risques (MeSH), Betacoronavirus (pathogénicité), Facteurs de risque (MeSH), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (anatomopathologie), Infections à coronavirus (complications), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (anatomopathologie), Pneumopathie virale (complications), Pneumopathie virale (mortalité), Pneumopathie virale (virologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Tumeurs (anatomopathologie), Tumeurs (mortalité), Tumeurs (virologie), Études prospectives (MeSH).
- MESH :
- anatomopathologie : Infections à coronavirus, Pneumopathie virale, Tumeurs.
- mortalité : Infections à coronavirus, Pneumopathie virale, Tumeurs.
- pathogénicité : Betacoronavirus.
- virologie : Infections à coronavirus, Pneumopathie virale, Tumeurs.
- complications : Adulte, Adulte d'âge moyen, Appréciation des risques, Facteurs de risque, Femelle, Hospitalisation, Humains, Infections à coronavirus, Mâle, Pandémies, Pneumopathie virale, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (pathogenicity), Coronavirus Infections (complications), Coronavirus Infections (mortality), Coronavirus Infections (pathology), Coronavirus Infections (virology), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Neoplasms (mortality), Neoplasms (pathology), Neoplasms (virology), Pandemics (MeSH), Pneumonia, Viral (complications), Pneumonia, Viral (mortality), Pneumonia, Viral (pathology), Pneumonia, Viral (virology), Prospective Studies (MeSH), Risk Assessment (MeSH), Risk Factors (MeSH).
- MESH :
- complications : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- pathogenicity : Betacoronavirus.
- pathology : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- virology : Coronavirus Infections, Neoplasms, Pneumonia, Viral.
- Adult, Aged, Aged, 80 and over, Female, Hospitalization, Humans, Male, Middle Aged, Pandemics, Prospective Studies, Risk Assessment, Risk Factors.
Abstract
BACKGROUND
Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.
METHODS
We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.
FINDINGS
319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).
INTERPRETATION
Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.
FUNDING
University of Birmingham and University of Oxford.
DOI: 10.1016/S1470-2045(20)30442-3
PubMed: 32853557
PubMed Central: PMC7444972
Affiliations:
- Royaume-Uni
- Angleterre, Grand Londres, Grand Manchester, Midlands de l'Ouest, Oxfordshire, Yorkshire-et-Humber, Écosse
- Birmingham, Leeds, Londres, Manchester, Oxford, Édimbourg
- University College de Londres, Université d'Oxford, Université d'Édimbourg, Université de Birmingham, Université de Leeds, Université de Manchester
Links toward previous steps (curation, corpus...)
Le document en format XML
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Hughes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Imaging, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cancer Imaging, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kerr, David" sort="Kerr, David" uniqKey="Kerr D" first="David" last="Kerr">David Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lee, Alvin J X" sort="Lee, Alvin J X" uniqKey="Lee A" first="Alvin J X" last="Lee">Alvin J X. Lee</name><affiliation wicri:level="4"><nlm:affiliation>UCL Cancer Institute, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Cancer Institute, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Lee, Rebecca J" sort="Lee, Rebecca J" uniqKey="Lee R" first="Rebecca J" last="Lee">Rebecca J. Lee</name><affiliation wicri:level="4"><nlm:affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Lee, Siow Ming" sort="Lee, Siow Ming" uniqKey="Lee S" first="Siow Ming" last="Lee">Siow Ming Lee</name><affiliation wicri:level="4"><nlm:affiliation>University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mckenzie, Hayley" sort="Mckenzie, Hayley" uniqKey="Mckenzie H" first="Hayley" last="Mckenzie">Hayley Mckenzie</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospital Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Middleton, Chris P" sort="Middleton, Chris P" uniqKey="Middleton C" first="Chris P" last="Middleton">Chris P. Middleton</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Murugaesu, Nirupa" sort="Murugaesu, Nirupa" uniqKey="Murugaesu N" first="Nirupa" last="Murugaesu">Nirupa Murugaesu</name><affiliation wicri:level="3"><nlm:affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's University Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Newsom Davis, Tom" sort="Newsom Davis, Tom" uniqKey="Newsom Davis T" first="Tom" last="Newsom-Davis">Tom Newsom-Davis</name><affiliation wicri:level="3"><nlm:affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Chelsea and Westminster Hospital NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olsson Brown, Anna C" sort="Olsson Brown, Anna C" uniqKey="Olsson Brown A" first="Anna C" last="Olsson-Brown">Anna C. Olsson-Brown</name><affiliation wicri:level="1"><nlm:affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Clatterbridge Cancer Centre, Birkenhead</wicri:regionArea><wicri:noRegion>Birkenhead</wicri:noRegion></affiliation></author><author><name sortKey="Palles, Claire" sort="Palles, Claire" uniqKey="Palles C" first="Claire" last="Palles">Claire Palles</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Powles, Thomas" sort="Powles, Thomas" uniqKey="Powles T" first="Thomas" last="Powles">Thomas Powles</name><affiliation wicri:level="3"><nlm:affiliation>Bart's Cancer Institute, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bart's Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Protheroe, Emily A" sort="Protheroe, Emily A" uniqKey="Protheroe E" first="Emily A" last="Protheroe">Emily A. Protheroe</name><affiliation wicri:level="3"><nlm:affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Birmingham Medical School, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Purshouse, Karin" sort="Purshouse, Karin" uniqKey="Purshouse K" first="Karin" last="Purshouse">Karin Purshouse</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sharma Oates, Archana" sort="Sharma Oates, Archana" uniqKey="Sharma Oates A" first="Archana" last="Sharma-Oates">Archana Sharma-Oates</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Inflammation and Ageing, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Sivakumar, Shivan" sort="Sivakumar, Shivan" uniqKey="Sivakumar S" first="Shivan" last="Sivakumar">Shivan Sivakumar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Smith, Ashley J" sort="Smith, Ashley J" uniqKey="Smith A" first="Ashley J" last="Smith">Ashley J. Smith</name><affiliation wicri:level="3"><nlm:affiliation>Consultancy Support, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Consultancy Support, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Topping, Oliver" sort="Topping, Oliver" uniqKey="Topping O" first="Oliver" last="Topping">Oliver Topping</name><affiliation wicri:level="3"><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Varnai, Csilla" sort="Varnai, Csilla" uniqKey="Varnai C" first="Csilla" last="Várnai">Csilla Várnai</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Briggs, Adam D M" sort="Briggs, Adam D M" uniqKey="Briggs A" first="Adam D M" last="Briggs">Adam D M. Briggs</name><affiliation wicri:level="1"><nlm:affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Middleton, Gary" sort="Middleton, Gary" uniqKey="Middleton G" first="Gary" last="Middleton">Gary Middleton</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Kerr, Rachel" sort="Kerr, Rachel" uniqKey="Kerr R" first="Rachel" last="Kerr">Rachel Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32853557</idno><idno type="pmid">32853557</idno><idno type="doi">10.1016/S1470-2045(20)30442-3</idno><idno type="pmc">PMC7444972</idno><idno type="wicri:Area/Main/Corpus">000463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000463</idno><idno type="wicri:Area/Main/Curation">000463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000463</idno><idno type="wicri:Area/Main/Exploration">000463</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.</title><author><name sortKey="Lee, Lennard Y W" sort="Lee, Lennard Y W" uniqKey="Lee L" first="Lennard Y W" last="Lee">Lennard Y W. Lee</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Cazier, Jean Baptiste" sort="Cazier, Jean Baptiste" uniqKey="Cazier J" first="Jean-Baptiste" last="Cazier">Jean-Baptiste Cazier</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Starkey, Thomas" sort="Starkey, Thomas" uniqKey="Starkey T" first="Thomas" last="Starkey">Thomas Starkey</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Briggs, Sarah E W" sort="Briggs, Sarah E W" uniqKey="Briggs S" first="Sarah E W" last="Briggs">Sarah E W. Briggs</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Arnold, Roland" sort="Arnold, Roland" uniqKey="Arnold R" first="Roland" last="Arnold">Roland Arnold</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Bisht, Vartika" sort="Bisht, Vartika" uniqKey="Bisht V" first="Vartika" last="Bisht">Vartika Bisht</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Booth, Stephen" sort="Booth, Stephen" uniqKey="Booth S" first="Stephen" last="Booth">Stephen Booth</name><affiliation wicri:level="4"><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Campton, Naomi A" sort="Campton, Naomi A" uniqKey="Campton N" first="Naomi A" last="Campton">Naomi A. Campton</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Translational Medicine, Birmingham Health Partners, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Translational Medicine, Birmingham Health Partners, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Cheng, Vinton W T" sort="Cheng, Vinton W T" uniqKey="Cheng V" first="Vinton W T" last="Cheng">Vinton W T. Cheng</name><affiliation wicri:level="4"><nlm:affiliation>Leeds Institute of Medical Research, University of Leeds, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Leeds Institute of Medical Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Collins, Graham" sort="Collins, Graham" uniqKey="Collins G" first="Graham" last="Collins">Graham Collins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Haematology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Haematology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Curley, Helen M" sort="Curley, Helen M" uniqKey="Curley H" first="Helen M" last="Curley">Helen M. Curley</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Earwaker, Philip" sort="Earwaker, Philip" uniqKey="Earwaker P" first="Philip" last="Earwaker">Philip Earwaker</name><affiliation wicri:level="3"><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Fittall, Matthew W" sort="Fittall, Matthew W" uniqKey="Fittall M" first="Matthew W" last="Fittall">Matthew W. Fittall</name><affiliation wicri:level="3"><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gennatas, Spyridon" sort="Gennatas, Spyridon" uniqKey="Gennatas S" first="Spyridon" last="Gennatas">Spyridon Gennatas</name><affiliation wicri:level="3"><nlm:affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Royal Marsden Hospital NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Goel, Anshita" sort="Goel, Anshita" uniqKey="Goel A" first="Anshita" last="Goel">Anshita Goel</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Hartley, Simon" sort="Hartley, Simon" uniqKey="Hartley S" first="Simon" last="Hartley">Simon Hartley</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Hughes, Daniel J" sort="Hughes, Daniel J" uniqKey="Hughes D" first="Daniel J" last="Hughes">Daniel J. Hughes</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cancer Imaging, King's College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cancer Imaging, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kerr, David" sort="Kerr, David" uniqKey="Kerr D" first="David" last="Kerr">David Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Lee, Alvin J X" sort="Lee, Alvin J X" uniqKey="Lee A" first="Alvin J X" last="Lee">Alvin J X. Lee</name><affiliation wicri:level="4"><nlm:affiliation>UCL Cancer Institute, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>UCL Cancer Institute, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Lee, Rebecca J" sort="Lee, Rebecca J" uniqKey="Lee R" first="Rebecca J" last="Lee">Rebecca J. Lee</name><affiliation wicri:level="4"><nlm:affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Lee, Siow Ming" sort="Lee, Siow Ming" uniqKey="Lee S" first="Siow Ming" last="Lee">Siow Ming Lee</name><affiliation wicri:level="4"><nlm:affiliation>University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mckenzie, Hayley" sort="Mckenzie, Hayley" uniqKey="Mckenzie H" first="Hayley" last="Mckenzie">Hayley Mckenzie</name><affiliation wicri:level="1"><nlm:affiliation>University Hospital Southampton, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospital Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Middleton, Chris P" sort="Middleton, Chris P" uniqKey="Middleton C" first="Chris P" last="Middleton">Chris P. Middleton</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Murugaesu, Nirupa" sort="Murugaesu, Nirupa" uniqKey="Murugaesu N" first="Nirupa" last="Murugaesu">Nirupa Murugaesu</name><affiliation wicri:level="3"><nlm:affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St George's University Hospitals NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Newsom Davis, Tom" sort="Newsom Davis, Tom" uniqKey="Newsom Davis T" first="Tom" last="Newsom-Davis">Tom Newsom-Davis</name><affiliation wicri:level="3"><nlm:affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Chelsea and Westminster Hospital NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Olsson Brown, Anna C" sort="Olsson Brown, Anna C" uniqKey="Olsson Brown A" first="Anna C" last="Olsson-Brown">Anna C. Olsson-Brown</name><affiliation wicri:level="1"><nlm:affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Clatterbridge Cancer Centre, Birkenhead</wicri:regionArea><wicri:noRegion>Birkenhead</wicri:noRegion></affiliation></author><author><name sortKey="Palles, Claire" sort="Palles, Claire" uniqKey="Palles C" first="Claire" last="Palles">Claire Palles</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Powles, Thomas" sort="Powles, Thomas" uniqKey="Powles T" first="Thomas" last="Powles">Thomas Powles</name><affiliation wicri:level="3"><nlm:affiliation>Bart's Cancer Institute, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Bart's Cancer Institute, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Protheroe, Emily A" sort="Protheroe, Emily A" uniqKey="Protheroe E" first="Emily A" last="Protheroe">Emily A. Protheroe</name><affiliation wicri:level="3"><nlm:affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Birmingham Medical School, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Purshouse, Karin" sort="Purshouse, Karin" uniqKey="Purshouse K" first="Karin" last="Purshouse">Karin Purshouse</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Sharma Oates, Archana" sort="Sharma Oates, Archana" uniqKey="Sharma Oates A" first="Archana" last="Sharma-Oates">Archana Sharma-Oates</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Inflammation and Ageing, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Sivakumar, Shivan" sort="Sivakumar, Shivan" uniqKey="Sivakumar S" first="Shivan" last="Sivakumar">Shivan Sivakumar</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Smith, Ashley J" sort="Smith, Ashley J" uniqKey="Smith A" first="Ashley J" last="Smith">Ashley J. Smith</name><affiliation wicri:level="3"><nlm:affiliation>Consultancy Support, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Consultancy Support, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Topping, Oliver" sort="Topping, Oliver" uniqKey="Topping O" first="Oliver" last="Topping">Oliver Topping</name><affiliation wicri:level="3"><nlm:affiliation>University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Varnai, Csilla" sort="Varnai, Csilla" uniqKey="Varnai C" first="Csilla" last="Várnai">Csilla Várnai</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Briggs, Adam D M" sort="Briggs, Adam D M" uniqKey="Briggs A" first="Adam D M" last="Briggs">Adam D M. Briggs</name><affiliation wicri:level="1"><nlm:affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Warwick Medical School, University of Warwick, Coventry</wicri:regionArea><wicri:noRegion>Coventry</wicri:noRegion></affiliation></author><author><name sortKey="Middleton, Gary" sort="Middleton, Gary" uniqKey="Middleton G" first="Gary" last="Middleton">Gary Middleton</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author><author><name sortKey="Kerr, Rachel" sort="Kerr, Rachel" uniqKey="Kerr R" first="Rachel" last="Kerr">Rachel Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Oncology, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Betacoronavirus (pathogenicity)</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Neoplasms (mortality)</term><term>Neoplasms (pathology)</term><term>Neoplasms (virology)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral (virology)</term><term>Prospective Studies (MeSH)</term><term>Risk Assessment (MeSH)</term><term>Risk Factors (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Appréciation des risques (MeSH)</term><term>Betacoronavirus (pathogénicité)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (complications)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (virologie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (anatomopathologie)</term><term>Pneumopathie virale (complications)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (virologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (mortalité)</term><term>Tumeurs (virologie)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasms</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prospective Studies</term><term>Risk Assessment</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Appréciation des risques</term><term>Facteurs de risque</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Infections à coronavirus</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.</p></div><div type="abstract" xml:lang="en"><p><b>FINDINGS</b></p><p>319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).</p></div><div type="abstract" xml:lang="en"><p><b>INTERPRETATION</b></p><p>Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.</p></div><div type="abstract" xml:lang="en"><p><b>FUNDING</b></p><p>University of Birmingham and University of Oxford.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32853557</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>13</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-5488</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>10</Issue><PubDate><Year>2020</Year><Month>10</Month></PubDate></JournalIssue><Title>The Lancet. Oncology</Title><ISOAbbreviation>Lancet Oncol</ISOAbbreviation></Journal><ArticleTitle>COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.</ArticleTitle><Pagination><MedlinePgn>1309-1316</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1470-2045(20)30442-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S1470-2045(20)30442-3</ELocationID><Abstract><AbstractText Label="BACKGROUND">Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients with cancer in the UK.</AbstractText><AbstractText Label="METHODS">We compared adult patients with cancer enrolled in the UK Coronavirus Cancer Monitoring Project (UKCCMP) cohort between March 18 and May 8, 2020, with a parallel non-COVID-19 UK cancer control population from the UK Office for National Statistics (2017 data). The primary outcome of the study was the effect of primary tumour subtype, age, and sex and on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prevalence and the case-fatality rate during hospital admission. We analysed the effect of tumour subtype and patient demographics (age and sex) on prevalence and mortality from COVID-19 using univariable and multivariable models.</AbstractText><AbstractText Label="FINDINGS">319 (30·6%) of 1044 patients in the UKCCMP cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case-fatality rate in patients with cancer after SARS-CoV-2 infection was significantly associated with increasing age, rising from 0·10 in patients aged 40-49 years to 0·48 in those aged 80 years and older. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours (odds ratio [OR] 1·57, 95% CI 1·15-2·15; p<0·0043). Compared with the rest of the UKCCMP cohort, patients with leukaemia showed a significantly increased case-fatality rate (2·25, 1·13-4·57; p=0·023). After correction for age and sex, patients with haematological malignancies who had recent chemotherapy had an increased risk of death during COVID-19-associated hospital admission (OR 2·09, 95% CI 1·09-4·08; p=0·028).</AbstractText><AbstractText Label="INTERPRETATION">Patients with cancer with different tumour types have differing susceptibility to SARS-CoV-2 infection and COVID-19 phenotypes. We generated individualised risk tables for patients with cancer, considering age, sex, and tumour subtype. Our results could be useful to assist physicians in informed risk-benefit discussions to explain COVID-19 risk and enable an evidenced-based approach to national social isolation policies.</AbstractText><AbstractText Label="FUNDING">University of Birmingham and University of Oxford.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Lennard Y W</ForeName><Initials>LYW</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Department of Oncology, University of Oxford, Oxford, UK; University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cazier</LastName><ForeName>Jean-Baptiste</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starkey</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briggs</LastName><ForeName>Sarah E W</ForeName><Initials>SEW</Initials><AffiliationInfo><Affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnold</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bisht</LastName><ForeName>Vartika</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campton</LastName><ForeName>Naomi A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Institute of Translational Medicine, Birmingham Health Partners, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Vinton W T</ForeName><Initials>VWT</Initials><AffiliationInfo><Affiliation>Leeds Institute of Medical Research, University of Leeds, Leeds, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collins</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Haematology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curley</LastName><ForeName>Helen M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Earwaker</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fittall</LastName><ForeName>Matthew W</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gennatas</LastName><ForeName>Spyridon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Royal Marsden Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goel</LastName><ForeName>Anshita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartley</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Computational Biology, University of Birmingham, Birmingham, UK; Advanced Research Computing, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hughes</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Cancer Imaging, King's College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Nuffield Division of Clinical and Laboratory Services, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Alvin J X</ForeName><Initials>AJX</Initials><AffiliationInfo><Affiliation>UCL Cancer Institute, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Rebecca J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>The University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Siow Ming</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mckenzie</LastName><ForeName>Hayley</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University Hospital Southampton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middleton</LastName><ForeName>Chris P</ForeName><Initials>CP</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murugaesu</LastName><ForeName>Nirupa</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>St George's University Hospitals NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newsom-Davis</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsson-Brown</LastName><ForeName>Anna C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>The Clatterbridge Cancer Centre, Birkenhead, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palles</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Powles</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Bart's Cancer Institute, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Protheroe</LastName><ForeName>Emily A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>University of Birmingham Medical School, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purshouse</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sharma-Oates</LastName><ForeName>Archana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sivakumar</LastName><ForeName>Shivan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Ashley J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Consultancy Support, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topping</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turnbull</LastName><ForeName>Chris D</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Nuffield Department of Medicine, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Várnai</LastName><ForeName>Csilla</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK; Centre for Computational Biology, University of Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Briggs</LastName><ForeName>Adam D M</ForeName><Initials>ADM</Initials><AffiliationInfo><Affiliation>Warwick Medical School, University of Warwick, Coventry, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Middleton</LastName><ForeName>Gary</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK; University Hospitals Birmingham, Birmingham, UK. Electronic address: g.middleton@bham.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerr</LastName><ForeName>Rachel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>UK Coronavirus Cancer Monitoring Project Team</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MR/P001106/1</GrantID><Acronym>MRC_</Acronym><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet Oncol</MedlineTA><NlmUniqueID>100957246</NlmUniqueID><ISSNLinking>1470-2045</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet Oncol. 2020 Sep 3;:</RefSource><PMID Version="1">32891190</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><InvestigatorList><Investigator ValidYN="Y"><LastName>Gault</LastName><ForeName>Abigails</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Agnieszka</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bedair</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ghaus</LastName><ForeName>Aisha</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Akingboye</LastName><ForeName>Akinfemi</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maynard</LastName><ForeName>Alec</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pawsey</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mohamed</LastName><ForeName>Ali Abdulnabi</ForeName><Initials>AA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Okines</LastName><ForeName>Alicia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Massey</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kwan</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferreira</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Angelakas</LastName><ForeName>Angelos</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wu</LastName><ForeName>Anjui</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tivey</LastName><ForeName>Ann</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Armstrong</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Madhan</LastName><ForeName>Annet</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pillai</LastName><ForeName>Annet</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Poon-King</LastName><ForeName>Ashley</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kurec</LastName><ForeName>Bartlomiej</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Usborne</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dobeson</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thirlwell</LastName><ForeName>Christina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sng</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scrase</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jingree</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brunner</LastName><ForeName>Clair</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fuller</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Griffin</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barrington</LastName><ForeName>Craig</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Muller</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ottaviani</LastName><ForeName>Diego</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gilbert</LastName><ForeName>Duncan</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tacconi</LastName><ForeName>Eliana</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Copson</LastName><ForeName>Ellen</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Renninson</LastName><ForeName>Emily</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cattell</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Burke</LastName><ForeName>Emma</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Smith</LastName><ForeName>Fiona</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Holt</LastName><ForeName>Francesca</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soosaipillai</LastName><ForeName>Gehan</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Boyce</LastName><ForeName>Hayley</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shaw</LastName><ForeName>Heather</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hollis</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bowyer</LastName><ForeName>Helen</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Anil</LastName><ForeName>Iris</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Illingworth Gibson</LastName><ForeName>Jack 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ValidYN="Y"><LastName>Banfill</LastName><ForeName>Kathryn</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Feeney</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Horsley</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cammaert</LastName><ForeName>Lauren</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Leena</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Eastlake</LastName><ForeName>Leonie</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Devereaux</LastName><ForeName>Louise</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Melcher</LastName><ForeName>Lucinda</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cook</LastName><ForeName>Lucy</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Teng</LastName><ForeName>Mabel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hewish</LastName><ForeName>Madeleine</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bhattacharyya</LastName><ForeName>Madhumita</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Choudhury</LastName><ForeName>Mahbuba</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baxter</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott-Brown</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fittall</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tilby</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rowe</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Agnieszka</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alihilali</LastName><ForeName>Mohammed</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galazi</LastName><ForeName>Myria</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yousaf</LastName><ForeName>Nadia</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chopra</LastName><ForeName>Neha</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cox</LastName><ForeName>Nicola</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chan</LastName><ForeName>Olivia</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sheikh</LastName><ForeName>Omar</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramage</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Greaves</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leonard</LastName><ForeName>Pauline</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hall</LastName><ForeName>Peter S</ForeName><Initials>PS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Naksukpaiboon</LastName><ForeName>Piangfan</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Corrie Peck</LastName><ForeName>Pippa Rahul</ForeName><Initials>PR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sharkey</LastName><ForeName>Rachel</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bolton</LastName><ForeName>Rachel</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sargent</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jyothirmayi</LastName><ForeName>Rema</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goldstein</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oakes</LastName><ForeName>Roderick</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shotton Kanani</LastName><ForeName>Rohan Ruhi</ForeName><Initials>RR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Board</LastName><ForeName>Ruth</ForeName><Initials>R</Initials></Investigator><Investigator 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Smith</name><name sortKey="Starkey, Thomas" sort="Starkey, Thomas" uniqKey="Starkey T" first="Thomas" last="Starkey">Thomas Starkey</name><name sortKey="Topping, Oliver" sort="Topping, Oliver" uniqKey="Topping O" first="Oliver" last="Topping">Oliver Topping</name><name sortKey="Turnbull, Chris D" sort="Turnbull, Chris D" uniqKey="Turnbull C" first="Chris D" last="Turnbull">Chris D. Turnbull</name><name sortKey="Varnai, Csilla" sort="Varnai, Csilla" uniqKey="Varnai C" first="Csilla" last="Várnai">Csilla Várnai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidSeniorV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000855 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000855 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidSeniorV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32853557
|texte= COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32853557" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidSeniorV1
| This area was generated with Dilib version V0.6.37. |  |